I used to load the 45-70 for several different rifles, from the "weak" Trapdoor to a Siamese Mauser I built. The one thing I learned was as far as hunting loads went, the old blackpowder load, 405 grain bullet and a 60-70 grain powder charge, was enough to give full penetration on the game I shot. So, why was I whacking myself half to death with "Magnum" loads? Since the light went on, I have stuck to blackpowder and been happy.
In the 45 Colt, I cast 3 or 4 different bullets but they all go over a full charge of black powder and again, give complete penetration on game animals, mostly the Ohio Whitetailed deer. My bullets are fairly soft, the alloy is usually 30/1.
Kevin